Program Details

9:00 a.m. Welcome and Opening Remarks

Irwin M. Arias, MD, Sangeeta Bhatia, MD, PhD & Wolfram Goessling, MD, PhD 

9:20 a.m. Organoid Medicine for Precision Hepatology

Takanori Takebe, MD, PhD

9:50 a.m. The Hepatocyte as a Household for Plasmodium Parasites

Maria Mota, PhD

10:20 a.m. Alpha-1 Antitrypsin Deficiency Associated Liver Disease (AATD-LD): Considerations for an siRNA-based Approach

Graham Heap, MBBS, PhD, MRCP

10:50 a.m. Micro-talks 

11:15 a.m. Liver Zonation in Health and Disease

Shalev Itzkovitz, PhD

11:45 a.m. Multicellular Tissue-Derived Liver Organoids to Study Interactions during Tissue Regeneration

Meri Huch, PhD

12:15 p.m. Fireside Chat

Irwin Arias, Sangeeta Bhatia & Wolfram Goessling

12:45 p.m. “Meet the Experts” 

Small-scale virtual lunch groups

1:30 p.m. Leveraging Energy Expenditure in the Management of Non-Alcoholic Fatty Liver Disease

David Cohen, MD, PhD

2:00 p.m. From Reading the Genome for Risk to Rewriting it for Cardiovascular Health 

Sekar Kathiresan, MD

3:30 p.m. Micro-talks 

3:00 p.m. A Matter of Architecture: How to build Epithelia with Hepatocytic Polarity

Anne Müsch, PhD

3:30 p.m. Therapeutic Opportunities in Glycoscience

Carolyn Bertozzi, PhD

4:00 p.m. Signals for Cell Proliferation in the Liver

Roel Nusse, PhD

4:30 p.m. Closing remarks 

Panelist Information

David E. Cohen, MD, PHD


Chief, Division of Gastroenterology, Hepatology and Endoscopy
Brigham and Women’s Hospital
Harvard Medical School
Editor-in-Chief, Hepatology

Symposium Topic:
Leveraging Energy Expenditure in the Management of
Non-Alcoholic Fatty Liver Disease

Graham Heap, MBBS, PhD, MRCP


Global Program Leader
Takeda Pharmaceutical Company

Symposium Topic:
ARO-AAT/TAK-999 in Patients With Alpha-1 Antitrypsin Deficiency
Associated Liver Disease (AATD-LD)

Meri Huch, PhD


Lise Meitner Max Planck Research Group Leader
Max Planck Institute of Molecular Cell Biology & Genetics
Pfotenhauerstrasse, Dresden

Symposium Topic:
Multicellular Tissue-Derived Liver Organoids Help Us Understanding
Cellular Interactions during Tissue Regeneration

Shalev Itzkovitz, PhD


HHMI International Research Scholar
Department of Molecular Cell Biology
Weismann Institute of Science
Rehovot, Israel

Symposium Topic:
Liver Zonation in Health and Disease

Sekar Kathiresan, MD

 

Co-Founder and Chief Executive Officer of  Verve Therapeutics

Symposium Topic:
From Reading the Genome for Risk to Rewriting it for Cardiovascular Health

Maria Mota, PhD


Maria M. Mota received her PhD degree in Molecular Parasitology from University College London in 1998, under the guidance of Anthony A Holder. She then moved to New York to pursue a postdoc at the New York University Medical Center and later in 2002 she started her own group at the Instituto Gulbenkian de Ciência (IGC), in Portugal. Currently, Maria is the Executive Director of Instituto de Medicina Molecular João Lobo Antunes (iMM) in Lisbon, and the leader of the research group Biology and Physiology of Malaria. Causative agent of malaria, interacts with its mammalian host. Some of the main questions her lab aims to understand are: What are the host mechanisms for sensing Plasmodium liver-stage infection? Does Plasmodium have evasion strategies to subvert host responses? How does Plasmodium fulfill its nutritional requirements to generate thousands of new parasites? Does
Plasmodium sense and respond to the host nutritional status? Maria has received several awards and honors throughout her career such as the European Science Foundation Young Investigator (EURYI) award in 2004,
Prémio Pessoa in 2013, EMBO member in 2016, Pfizer award in 2017 and Sanofi – Institut Pasteur 2018 Award in the Mid-Career category.

Symposium Topic: The Hepatocyte as a Household for Plasmodium Parasites

Anne Müsch, PhD


Professor of Molecular and Developmental Biology at Einstein Medical College, Bronx NY
Postdoctoral Training in Epithelial Cell Biology at Cornell Medical College NY
PhD in Cell Biology from Humboldt University Berlin, Germany

Symposium Topic:
A Matter of Architecture: How to build Epithelia with Hepatocytic Polarity

Roel Nusse, PhD


Professor of Developmental Biology
Stanford University, School of Medicine
Investigator, Howard Hughes Medical Institute

Symposium Topic:
Signals for Cell Proliferation in the Liver

Takanori Takebe, MD, PhD


Director of Commercial Innovation in Center for Stem Cell &
Organoid Medicine
Associate Professor and Endowed Chair of Organoid Medicine
Cincinnati Children’s Hospital Medical Center

Also:

Professor at Institute of Research at Tokyo Medical and Dental University
Founding Director, Communication Design Center, Yokohama City University

Symposium Topic:
Organoid Medicine for Precision Hepatology

Historical Speakers

2019 SPEAKERS

Steven Artandi, MD, PhD
Sudha Biddinger, MD, PhD
Kathleen Corey, MD, MPH, MMSc
Russell Goodman, MD, DPhil
Yasuko Iwakiri, PhD
Sonya MacParland, PhD
Harith Rajagopalan, MD, PhD
Orit Rozenblatt-Rosen, PhD
Alfica Sehgal, MSc, PhD
Laura Sepp-Lorenzino, PhD
Ludovic Vallier, PhD
Rebecca Wells, MD

 

2018 SPEAKERS

Regina Barzilay
Wolfram Goessling, MD, PhD
Kristen Knouse, MD, PhD
Natalie Porat Shilom, PhD
Simon Robson, MD, PhD, FRCP
Gyongyi Szabo, MD, PhD, FACP
Luk Vandenberghe, PhD
Holger Willenbring, MD, PhD
Ramnik Xavier, MD 

2017 SPEAKERS

Galit Alter, PhD
Nabeel Bardeesy, PhD
Raymond Chung, MD
David Cohen, MD, PhD
Valerie Gouon-Evans, PharmD, PhD
Patrick Haslett, MD
Allan Mullen, MD, PhD
Kristin Sadler Edepli, PhD
Kimberly Tremblay, PhD
Chinweike Ukomadu, MD, PhD