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2019/11/13 08:30:00

Program Details

29th Annual Irwin M. Arias Symposium

Location: Broad Institute, 415 Main Street, Cambridge, MA 02142
Date: November 13, 2019
Time: 8:30 am - 5:00 pm

8:30-9:00 a.m. Registration

9:00 a.m. Welcome and Opening Remarks

9:05 a.m. The Role of Lymphatic Vessels in the Liver, Yasuko Iwakiri, PhD, Yale University

9:30 a.m. NAFLD and Cardiovascular Disease, Kathleen Corey, MD, MPH, MMSc Massachusetts General Hospital

9:55 a.m. Deciphering Transcriptional Control for Therapeutic Modulation of Liver Disease Genes, Alfica Sehgal, MSc, PhD CAMP4 Therapeutics

10:20 a.m. Morning Break

10:45 a.m. The Duodenum as a Therapeutic Target for Metabolic Liver Disease, Harith Rajagopalan, MD, PhD, Fractyl

11:10 a.m. Thinking About Fatty Liver Disease Mechanically, Rebecca Wells, MD, University of Pennsylvania

11:35 a.m. Insulin Resistance in the Development and Progression of NAFLD, Sudha Biddinger, MD, PhD, Boston Children’s Hospital, Harvard Medical School

12:00 p.m. Poster Teaser

12:10 p.m. Lunch and Poster Session

  • Poster submissions will be accepted at the time of registration
  • Undergraduate and Graduate students as well as Trainees, Residents, and Fellows are encouraged to submit poster abstracts
  • We will accept up to 40 poster submissions
  • The deadline for submission is November 1
  • Each accepted poster will have a 4′ x 3′ space

Check back after October 21st to find out what posters will be displayed at our 29th Annual Irwin M. Arias Symposium!

Questions? Please e-mail Lindsay Ventura at

1:30 p.m. Hepatic Reductive Stress Underlies Common Metabolic Traits and Diseases, Russell Goodman, MD, DPhil, Massachusetts General Hospital, Harvard Medical School

1:55 p.m. Cell Atlases as Roadmaps to Understand Tumors, Orit Rozenblatt-Rosen, PhD, Klarman Cell Observatory, Broad Institute

2:20 p.m. The Power and Promise of CRISPR/cas9: Intellia’s Progress in Therapeutic Liver Genome Editing, Laura Sepp-Lorenzino, PhD, Intellia Therapeutics, Inc.

2:45 p.m. Afternoon Break

3:00 p.m. Distributed Hepatocytes in Liver Homeostasis and Regeneration, Steven Artandi, MD, PhD, Stanford University

3:25 p.m. Understanding Human Liver Development to Produce Hepatocytes In Vitro, Ludovic Vallier, PhD, Cambridge Stem Cell Institute, University of Cambridge

3:50 p.m. Generating an Atlas of Human Liver Diversity, Sonya MacParland, PhD, Toronto General Hospital Research Institute

4:15 p.m. Concluding remarks and adjourn

4:30 p.m. Reception

Join Us After the Symposium for a Film Screening

Faculty Information

Steven Artandi, MD, PhD

Director, Stanford Cancer Institute
Jerome and Daisy Low Gilbert Professor
Professor of Biochemsitry
Professor of Medicine-Hematology
Stanford University School of Medicine

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Sudha Biddinger, MD, PhD

Medical Staff
Boston Children’s Hospital
Associate Professor of Pediatrics
Harvard Medical School

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Kathleen Corey, MD, MPH, MMSc

Director, MGH Fatty Liver Clinic
Gastrointestinal Unit
Massachusetts General Hospital
Assistant Professor of Medicine
Harvard Medical School

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Russell Goodman, MD, DPhil

Instructor, Harvard Medical School
Division of Gastroenterology
Massachusetts General Hospital

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Yasuko Iwakiri, PhD

Associate Professor of Medicine (Digestive Diseases)
Internal Medicine: Diabetes Research Center
Digestive Diseases: Iwakiri Lab
Liver Center
Yale Tissue Regeneration and Fibrosis Program
Yale School of Medicine
Yale University

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Sonya MacParland, PhD

Toronto General Hospital Research Institute
University Health Network, Toronto

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Harith Rajagopalan, MD, PhD

Co-Founder and Chief Executive Officer

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Orit Rozenblatt-Rosen, PhD

Scientific Director, Klarman Cell Observatory
Associate Director, Cell Circuits Program
Lead Scientist, Human Cell Atlas Initiative
Institute Scientist
Broad Institute

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Alfica Sehgal, MSc, PhD

Director, Head of Translational Sciences
CAMP4 Therapeutics

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Laura Sepp-Lorenzino, PhD

Executive Vice-President
Chief Scientific Officer
Intellia Therapeutics

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Ludovic Vallier, PhD

Senior Group Leader
Cambridge Stem Cell Institute
Wellcome Sanger Institute
Director, Cambridge Biomedical Research Centre
Professor, Regenerative Medicine
Department of Surgery
University of Cambridge

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Rebecca Wells, MD

Vice Chief for Research in Gastroenterology
Professor of Medicine (Gastroenterology)
Pathology and Laboratory Medicine
Perelman School of Medicine
University of Pennsylvania

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