Agenda
- 8:30 Arrival and registration
- 9:00 Sangeeta N Bhatia, MD, PhD, MIT/HHMI & Wolfram Goessling, MD, PhD, Harvard/MGH: Opening remarks
- 9:10 Harvey J. Alter, MD, MACP, National Institute of Health: Hepatitis C: Then, Now and Beyond
- 9:35 Charles Rice, PhD, Rockefeller University: A New Model for Studying Hepacivirus-associated Liver Cancer
- 10:00 coffee & poster break
- 10:15 Pamela Hoodless, PhD, University of British Columbia: Gene Regulatory Dynamics in Hepatic Specification
- 10:40 Hien Dang, PhD, Thomas Jefferson University: Leveraging Splicing to Target HCC
- 11:05 Kendra Bence, PhD, Pfizer: Role of the Hepatokine Inhibin E (INHBE) in Liver-Adipose Interorgan Communication
- 11:30 3x 3 minute microtalks – trainees (online or in person)
- 11:45 lunch buffet & posters/judging
- 1:30 Markus Grompe, MD, Oregon Health and Science University: Cell Therapy with Genetically Enhanced Hepatocytes
- 1:55 Valerie Gouon-Evans, PhD, PharmD, Boston University: Treatment of Liver Diseases with mRNA-encoded Factors.
- 2:20 3-5x 3 minute microtalks – trainees (online or in person)
- 2:45 coffee & poster break
- 3:00 Rotonya Carr, MD, FACP, University of Washington: Lipid Metabolic Regulators of Steatotic Liver Disease
- 3:25 David Lloyd, PhD, Insitro: NAFLD Deconstructed: Use of Advanced Clinical Machine Learning to Reveal Novel Pathobiology
- 3:50 Irwin Arias, MD, National Institute of Health: Hepatocyte Polarity: Neglected, Unique, Complex and Critical
- 4:15 Closing remarks & poster prizes
- 4:30 Reception & wine and cheese
- 5:30 Departure
Join this one-day virtual event to hear from leading biomedical scientists and physicians as they present critical research bridging basic science and liver disease.
Plenary speakers include:
Adjoa Anyane-Yeboa, MD MPH
Institution: Division of Gastroenterology Department of Medicine Massachusetts General Hospital Harvard Medical School
Lew Cantley, PhD
Institution: Dana Farber Cancer Institute
Presentation Title: Altered liver metabolism confounds the effectiveness of PI3K inhibitors for treating breast and endometrial cancers
Hans Clevers, PhD
Institution: Roche/Hubrecht Institute
Presentation Title: Organoids to model human diseases
Nikla Emambokus, PhD
Institution: Editor-in-Chief, Med; Executive Editor Med, Cell Metabolism
Heather Francis, PhD
Institution: Indiana University
Presentation Title: Regulation of Chronic Liver Disease and Cholangiopathies by Mast Cells
Stacey Huppert, PhD
Institution: Cincinnati Children’s
Presentation Title: Hepatic Epithelial Development and Plasticity- Identity and Commitment
Sonja Schrepfer, MD, PhD
Institution: Cincinnati Children’s
Presentation Title: Protecting transplanted cells from immune rejection is the key to unlocking the potential of regenerative medicine
Bao-Liang Song, PhD
Institution: Wuhan University
Presentation Title: Inhibition of ASGRI decreases lipid levels by promoting cholesterol excretion
Elizabeth K Speliotes MD, PhD, MPH
Institution: University of Michigan
Presentation Title: Genetic Subtyping of NAFLD
Joseph Takahashi, PhD
Institution: UT Southwestern
Presentation Title: Circadian clocks and their importance for metabolism, aging and longevity
Giovanni Traverso, MD, PhD
Institution: MIT, Brigham & Women’s Hospital, Harvard Medical School
Presentation Title: Explant liver model for drug development
Aubrey Weigel, PhD
Institution: Howard Hughes Medical Institute
Presentation Title: Towards Automatic Segmentation of Organelles in vEM
Hao Zhu, MD, PhD
Institution: UT Southwestern
Presentation Title: Clone Wars: Evolution of Adaptation and Malignancy in the liver
Hosted by:
- Sangeeta Bhatia, MD, PhD – Massachusetts Institute of Technology
- Wolfram Goessling, MD, PhD – Massachusetts General Hospital
Agenda
November 10, 2022 – Live, on Zoom (times EST)
- 09:00 – INTRODUCTORY COMMENTS:
Sangeeta Bhatia, MIT, Irwin Arias, NIH, Lorraine Stiehl, ALF - 09:15 – Hao Zhu, University of Texas Southwestern
Clone Wars: Evolution of Adaptation and Malignancy in the Liver - 09:45 – Bao-Liang Song, Wuhan University School of Medicine
Inhibition of ASGRI decreases lipid levels by promoting cholesterol excretion - 10:15 – Heather Francis, Indiana University School of Medicine
Regulation of Chronic Liver Disease and Cholangiopathies by Mast Cells - 10:45 – Microtalks from abstracts (2 slides/3 minutes)
Joanna Krawczyk, Boston Children’s Hospital, Biddinger lab
Insulin regulates bile acid metabolism through zone-specific transcriptional programs - 10:50 – BREAK
- 11:00 – Stacey Huppert, Cincinnati Children’s Hospital
Hepatic Epithelial Development and Plasticity – Identity and Commitment - 11:30 – Hans Clevers, Roche/Hubrecht Institute
Organoids to model human diseases - 12:00 – Aubrey Weigel, Howard Hughes Medical Institute
Towards Automatic Segmentation of Organelles in vEM - 12:30 – Microtalks from abstracts (2 slides/3 minutes)
William (Will) Schneider, Rockefeller, Rice lab
An RNA-based system to study hepatitis B virus replication and evaluate antivirals - 12:35 – BREAK
- 13:00 – ROUNDTABLE DISCUSSION: ‘Meet Me on the Bridge’
Irwin Arias, National Institutes of Health
Adjoa Anyane-Yeboa, Massachusetts General Hospital
Sangeeta Bhatia, MIT
Wolfram Goessling, Massachusetts General Hospital
Moderator: Nikla Emambokus, Med, Cell Press - 13:30 – Elizabeth Speliotes, University of Michigan Health
Genetic Subtyping of NAFLD - 14:00 – Joseph Takahashi, University of Texas Southwestern
Circadian clocks and their importance for metabolism, aging and longevity - 14:30 – Microtalks from abstracts (2 slides/3 minutes)
Scott Freeburg, Brigham & Women’s Hospital, Goessling lab
Hepatocyte Vitamin D Receptor in the regulation of energy metabolism
Shuang (Sammi) Wang, Mt Sinai, Friedman lab
An autocrine signaling circuit in hepatic stellate cells underlies advanced fibrosis
Sujin Park, Basel, Hall lab
Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis - 14:45 – BREAK
- 15:00 – Gio Traverso, Harvard Medical School
Title TBD - 15:30 – Sonja Schrepfer, Sana Biotechnology
Protecting transplanted cells from immune rejection is the key to unlocking the potential of regenerative medicine - 16:00 – Lew Cantley, Dana Farber Cancer Institute
Altered liver metabolism confounds the effectiveness of PI3K inhibitors for treating breast and endometrial cancers - 16:40 – CLOSING COMMENTS: Wolfram Goessling, MGH